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BPA Causes “Demasculinization” in Male Mice

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Male mice exposed in the womb to bisphenol A, or BPA, appear to be less masculine and less attractive to females once they mature, according to a new study.

The findings raise the possibility that the controversial chemical could subtly affect boys in similar ways.

In a new study, male deer mice whose mothers were fed BPA, a chemical compound found in some hard plastics and can linings, while pregnant had more difficulty navigating a maze and displayed less interest in exploring than unexposed males. This is said to be a sign of “demasculinization,” researchers say, since navigational skill and interest in exploration are considered classic male traits in this particular species of mice.

This reduction in masculinity appears to make BPA-exposed mice less attractive to those potential mates.

In a different experiment, female mice who were released into cages containing two male mice, only one of which was exposed to BPA, spent roughly half as much time in “nose-to-nose contact with the BPA-exposed mice. Researchers say this may be due to the fact that females sensed differences in their behavior, pheromones, or both.

In the study, published Monday on the website of the journal Proceedings of the National Academy of Sciences, researchers urged that it is too soon to tell exactly how these findings might translate to humans, if at all. disclaimer: This article: BPA Causes “Demasculinization” in Male Mice was posted on Tuesday, June 28th, 2011 at 3:35 pm at and is filed under Uncategorized.

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